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Although stacking creatine may be used primarily during the loading phase of creatine, many bodybuilders use this strategy for long periods of time. If the bodybuilder is training to improve overall training effects, but he does not intend to enhance the size gain, then the creatine should remain available throughout the loading phase. The Bottom Line Creatine is a natural ingredient used by many bodybuilders, which aids in protein synthesis and muscle adaptation and stimulates muscle to creatine production, front loading test e. Creatine loading is a highly effective way of increasing muscle mass. For this reason, the addition of creatine supplements to a typical bodybuilding training program is recommended.